Affiliated fairs are members of the Society for Science network. These competitions exist in nearly every state in the United States as well as over 70 other countries, regions and territories. Fairs are conducted at local, regional, state and national levels and can be affiliated with the International Science and Engineering Fair (ISEF) and/or the Thermo Fisher Scientific Junior Innovators Challenge. To compete at ISEF, a 9th-12th grade student must first win the honor through participation at a Society-affiliated fair. Each affiliated fair has a designated number of projects (individual or team) that they may support to come to ISEF.

The Regeneron Science Talent Search proudly identifies future leaders in science, and awards deserving students and their schools with $3.1 million each year. The first place prize is $250,000—the largest scientific prize available to a high school student in the United States.